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Stacking Psilocybin with Lion’s Mane & Niacin: Does It Work?
Intro: The Rise of the Stamets Stack
In the world of psychedelics and nootropics, one combo stands out: psilocybin + lion’s mane + niacin. Popularized by renowned mycologist Paul Stamets, this “stack” is designed to support neurogenesis (the growth of new brain cells) while gently enhancing cognition and emotional resilience.
But is it legit? And how should you use it—for microdosing, macrodosing, or both?
Let’s break down the stack, its potential benefits, and how to integrate it into your own wellness routine.
What Is the Stamets Stack?
The classic Stamets Stack includes:
- Psilocybin – A psychedelic compound that interacts with serotonin receptors and may promote brain plasticity
- Lion’s Mane – A medicinal mushroom known for its nerve growth factor (NGF)-boosting effects
- Niacin (Vitamin B3) – Helps deliver the other two compounds into peripheral tissues via “flushing”
Stamets theorized that combining these three could stimulate brain regeneration, improve mental health, and even support long-term neurological repair.
🌿 Try it: Stamets Stack Capsules — pre-formulated with optimal doses of all three ingredients.
Potential Benefits of the Stack
While clinical trials are limited, anecdotal evidence and early research suggest this combo may support:
- Enhanced cognitive function
- Improved mood and emotional regulation
- Increased creativity and memory
- Potential neurogenesis and brain plasticity
- Reduced symptoms of depression and anxiety
The niacin component may also help distribute psilocybin and lion’s mane more evenly throughout the body, promoting a whole-system reset.
Should You Use the Stack for Microdosing or Macrodosing?
Microdosing:
This is the most common use case. People report greater emotional balance and mental sharpness when stacking during their microdosing protocol.
Schedule Suggestion (Stamets Method):
- 4 days on
- 3 days off
- Repeat weekly for 4–6 weeks, then pause
🧠 Start here: Neurodose Adaptogen Blend – a gentler, stack-inspired formula designed for daily emotional support.
Macrodosing:
Some users experiment with stacking prior to or during a full-dose journey, especially for cognitive healing purposes. However, the flush from niacin can intensify sensations, so this is best for experienced users only.
How It Feels (User Feedback)
“The fog started to lift after just a week.”
“I’m more emotionally stable without feeling numb.”
“Less anxiety, more focus—without relying on caffeine.”
“Niacin flush is real, but it feels like a reset.”
Are There Any Risks or Drawbacks?
The stack is generally well-tolerated, but:
- Niacin can cause temporary flushing, tingling, or redness
- People with low blood pressure or sensitivity to B vitamins should start slow
- Always consult your doctor if you’re on medications or have neurological conditions
- Avoid long-term daily use without breaks—cycling is important
Tips for Best Results
- Take in the morning with water
- Use a structured schedule (like 4 days on / 3 days off)
- Combine with meditation, journaling, or therapy for deeper integration
- Track your mood, sleep, and energy over time
🔁 Want to ease into it? Start with Psilocybin 100mg Capsules and stack lion’s mane separately to test sensitivity.
Final Thoughts: Nature’s Nootropic Stack
Stacking psilocybin with lion’s mane and niacin isn’t just trendy—it’s rooted in both ancient medicine and modern neuroscience. Whether you’re microdosing for daily balance or preparing for a deeper journey, this trio may support brain health, creativity, and emotional clarity.
At Neurodose, we offer pre-formulated stacks and blends built for precision, safety, and real results.